Physical, chemical and kinetic factors affecting prion infectivity
نویسندگان
چکیده
منابع مشابه
Physical, chemical and kinetic factors affecting prion infectivity
The mouse-adapted scrapie prion strain RML is one of the most widely used in prion research. The introduction of a cell culture-based assay of RML prions, the scrapie cell assay (SCA) allows more rapid and precise prion titration. A semi-automated version of this assay (ASCA) was applied to explore a range of conditions that might influence the infectivity and properties of RML prions. These in...
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Interactions between normal, protease-sensitive prion protein (PrP-sen or PrP(C)) and its protease-resistant isoform (PrP-res or PrP(Sc)) are critical in transmissible spongiform encephalopathy (TSE) diseases. To investigate the propagation of PrP-res between cells we tested whether PrP-res in scrapie brain microsomes can induce the conversion of PrP-sen to PrP-res if the PrP-sen is bound to un...
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Prion diseases are transmissible neurodegenerative disorders of humans and animals for which no effective treatment is available. Conformationally altered, protease-resistant forms of the prion protein (PrP) termed PrP(Sc) are critical for disease transmissibility and pathogenesis, thus representing a primary target for therapeutic strategies. Based on previous findings that tetracyclines rever...
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Entomopathogenic nematode in vivo production depends on a high level of successful infection during the inoculation process. Some host–nematode combinations do not provide suYcient or consistent infection levels and are, therefore, not suitable for in vivo production. Our objective was to determine whether infection levels could be improved through host or nematode exposure to physical and chem...
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Background: Today, the special position of sports in different societies is not hidden from anyone (4). Football is one of these sports that plays the first role (5). In the world of sports, people play an important role and one of these important human resources is referees, and football is no exception. In fact, the fair judgment of the referees plays an important role in the view of athletes...
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ژورنال
عنوان ژورنال: Prion
سال: 2016
ISSN: 1933-6896,1933-690X
DOI: 10.1080/19336896.2016.1181250